The evolution of limb morphology and function has played a crucial role in the evolutionary diversification of vertebrates. Whereas the molecular mechanisms of limb patterning are well studied, two key questions remain unresolved: how the molecular circuitry of appendage patterning first appeared and how this genetic toolkit constructs different limb/fin morphologies.
To help elucidate these questions, I'm interested in studying basal extant groups of vertebrates, such as lampreys and sharks, with a special focus in regulatory sequences that may have played a role in vertebrate appendage evolution.
Schneider, I., I. Aneas, A.R. Gehrke, R.D. Dahn, M.A. Nobrega, and N.H. Shubin. Appendage expression driven by the Hoxd Global Control Region is an ancient gnathostome feature. PNAS 108(31), 12782-12786 (2011). (PubMed)
Schneider, I., P.N. Schneider, S.W. Derry, S. Lin, L.J. Barton, T. Westfall and D.C. Slusarski. Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. Developmental Biology 348(1): 22-33 (2010). (PubMed)
Schneider, I., D.W. Houston, M. Rebagliati, and D.C. Slusarski. Calcium fluxes in dorsal forerunner cells antagonize beta-catenin and alter left-right patterning. Development 135(1): 75-84 (2008). (PubMed)
Freisinger, C.M, I. Schneider, T.A. Westfall, and D.C. Slusarski. Calcium integrated into signaling pathways that influence vertebrate axial patterning. Philosophical Transactions of the Royal Society B 363(1495): 1377-1385 (2008). [Journal Cover] (PubMed)
Zhang, Y., J.R. Yeh, A. Mara, R. Ju, J.F. Hines, P. Cirone, H.L. Griesbach, I. Schneider, D.C. Slusarski, S.A. Holley, C.M. Crews. A chemical and genetic approach to the mode of action of fumagillin. Chemical Biology 13(9): 1001-1009 (2006). [Journal Cover]
Schneider, I., H. Schneider, M.P. Schneider, and A. Silva. The prion protein and New World primate phylogeny. Genetic Molecular Biology 27(4): 505-510 (2004).